Holmes’ Tremor Due to Metastatic Lung Cancer: A Case Report
Didem TAŞKIN,1 Nesrin HELVACI YILMAZ,1 Lütfü HANOĞLU,1 Fahriye Feriha ÖZER,2 Özdil BAŞKAN,3 Özcan YILDIZ,4 Sema DEMİRCİ,1 Burcu POLAT1
1Medipol Üniversitesi Nöroloji Anabilim Dalı, İstanbul, Türkiye
2Ordu Üniversitesi Nöroloji Anabilim Dalı, Ordu, Türkiye
3Medipol Üniversitesi Radyoloji Anabilim Dalı, İstanbul, Türkiye
4Medipol Üniversitesi Tıbbi Onkoloji Anabilim Dalı, İstanbul, Türkiye
Keywords: Cerebellum; cerebral peduncle; Holmes’ tremor; lung cancer.
Abstract
Holmes' tremor is a form of low-frequency tremor originating from various brainstem, cerebellum and thalamus lesions. Tremor is often resistant to drug therapy. A 61-year-old female patient was admitted to our clinic with Holmes’ tremor. Cranial magnetic resonance imaging showed hemorrhagic lesions localized in the left cerebral peduncle and cystic lesions localized in the anterior and posterior right cerebellar hemisphere. Based on the examination findings, she was diagnosed with lung adenocarcinoma and radiotherapy and chemotherapy along with corticosteroid therapy were initiated. The tremor was resolved completely within three months. We suggest that paraneoplastic causes in the etiology of Holmes tremor should also be kept in mind.