Tic Disorder Following Aripiprazole Therapy
Hasan MERAL,1 Tuba AYDEMİR ÖZCAN,2 Kürşat ALTINBAŞ,3 Meltem DURAKLI ULUKÖK,4 Feriha ÖZER2
1Çanakkale Anadolu Hastanesi, Nöroloji Kliniği, Çanakkale, Türkiye
2Ordu Üniversitesi Tıp Fakültesi Nöroloji Anabilim Dalı, Ordu, Türkiye
3Çanakkale Onsekiz Mart Üniversitesi Tıp Fakültesi Psikiyatri Anabilim Dalı, Çanakkale, Türkiye
4Çankaya Tıp Merkezi, Nöroloji Kliniği, İzmir, Türkiye
Keywords: Aripiprazole; obsessive-compulsive disorder; tic disorder.
Abstract
Aripiprazole is a potent anti-psychotic which exerts partial agonistic activity on serotonin 1A receptor and dopamine D2 receptor and antagonistic activity on serotonin receptors 2A. Tic disorder is a clinical entity including chronic motor/vocal, transient tic disorder not otherwise specified. Psychostimulants and levodopa may increase the tics by promoting dopaminergic activity. In this article, we report a 22-year-old male case of tic disorder who was diagnosed with obsessive-compulsive disorder without tics previously and experienced tic disorder after aripiprazole therapy. Aripiprazole, which has been widely used in the treatment of motor tic disorders in recent years may paradoxically cause tic disorder.