Abstract

Atypical parkinsonism syndromes are progressive neurodegenerative syndromes that generally do not respond well to levodopa treatment and in which other signs and symptoms are added to the classical findings of Parkinson’s disease. Atypical parkinsonism syndromes include multiple system atrophy, progressive supranuclear palsy, corticobasal degeneration, and dementia with Lewy bodies. These diseases are associated with abnormal protein deposition in brain cells. Signs suggestive of atypical parkinsonism syndromes in a patient with parkinsonism findings should be well recognized, and the approach should be planned accordingly. There is no treatment that affects the progression of atypical parkinsonism syndromes yet. Supportive physiotherapy and occupational therapy can help patients cope with their symptoms. It is also crucial to maximize the patient’s ability to swallow and treat psychiatric symptoms.