The Relationship Between Parkinson’s Disease and Mean Platelet Volume
Sırma GEYİK,1 Remzi YİĞİTER,1 Gamze Pınar AKGÜL,2 Mehmet Ali ELÇİ,3Yasemin EKMEKYAPAR FIRAT1
1Department of Neurology, Medical Faculty of Gaziantep University, Gaziantep, Turkey
2Department of Neurology, Dr. Ersin Arslan State Hospital, Gaziantep, Turkey
3Department of Neurology, Kırıkhan State Hospital, Antakya, Turkey
Keywords: Disease activity; mean platelet volume; Parkinson’s disease; platelet count.
Abstract
Objectives: This study aims to investigate whether mean platelet volume (MPV) in peripheral blood of patients with Parkinson’s disease (PD) is an indicator of the disease and the severity of disease.
Patients and Methods: Between April 2013 and June 2014, a total of 80 patients diagnosed with Parkinson’s disease and 80 healthy volunteers for control group were enrolled in this study and their blood measurements were compared. Parkinson’s disease patients were examined by using Hoehn and Yahr scale (HYS), which is a scale for Parkinson’s disease severity.
Results: Platelet count and MPV were found similar between the groups. Mean platelet volume correlated negatively with HYS score (p<0.001, r= -0.576).
Conclusion: Vascular risk factors may not play a role in the pathogenesis of PD. The negative relationship between the severity of disease and MPV suggested that the inflammation theory might play a more important role in the later stages of the disease.