Journal of Parkinson's Disease and Movement Disorders

Ayşegül GÜNDÜZ,1 Bashar ABUZAYED,2 Semra OĞUZ,1 Sabri AYDIN,2 Reza POUR MOHAMMAD,1Orhan YAĞIZ,3 Güneş KIZILTAN,1 Hülya APAYDIN,1 Sibel ERTAN1

İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi 1Nöroloji Anabilim Dalı, 2Nöroşirurji Anabilim Dalı, İstanbul, Türkiye;
3İstanbul Eğitim ve Araştırma Hastanesi Nöroloji Kliniği, İstanbul, Türkiye

Keywords: Cerebrovascular diseases; Holmes tremor; midbrain; thalamus.


Holmes’ tremor is a low frequency tremor which is diagnosed clinically, appears during rest, posture and action on especially proximal parts. It is generally associated with lesions (cerebrovascular diseases, trauma or multiple sclerosis) localized in midbrain or thalamus. Symptoms generally develop weeks, months and even years after the underlying cause. In this article, a case of Holmes’ tremor which developed approximately five months after the hemorrhage localized at upper part of midbrain secondary to cavernoma and the clinical and electrophysiological features, etiological factors and medical and surgical treatments of Holmes’ tremor is presented in the light of the literature.