Abstract

It has been reported that apomorphine infusion should be considered as an alternative treatment in an advanced stage with decreased clinical response to oral treatment options of Parkinson’s disease. In this report a female patient with advanced Parkinson’s disease who has been successfully administered apomorphine infusion is presented. A 50-year-old woman with Parkinson’s disease was admitted to our clinic due to severe tremor and frequent dyskinesia. A subcutaneous apomorphine infusion therapy was initiated at dose of 80 mg for 14 hours daily. On the 34^th therapy day, Unified Parkinson’s Disease Rating Scale-motor score decreased to 2.0 and the frequency of dyskinesia fell to 5% of the waking day. Off-time reduced to 10% of the waking day, with an improvement of 85.6% from baseline and on-time increased 80% from baseline, with functionality maintained for 95% of the waking day. The patient exhibited no adverse events, expect for mild dermal reactions on the administrationsite. Our case confirmed the previous study results reporting that continuous subcutaneous apomorphine infusion leaded to improvement in patients’ neurological conditions in advanced Parkinson’s disease.